To answer Julie's original question, I don't think I've ever had any readers (at least the ones who actually give feedback) not like one of my female characters. Quite the opposite, actually. I had a lot of people reading FILA tell me how much they really liked Annie. I actually worry that any new readers for Run are having a hard time liking Annie because they just don't "know" her the way the FILA readers do, because the previous story is the one that really developed this character. In Forever, I can see that some readers simply don't care for the more minor female characters, because they know the narrator female character so well. If anyone doesn't like that character, they've not told me about it. I've already discussed the fact that I do like to write more "female-centered" stories, so I think it's important that the female character IS someone who is likeable. In my own reading, I have a hard time liking female characters who are really needy, too forgiving (or too unforgiving) of the Boys. I hate those characters who become sort -of a victim to one of them-- who will give up her own morals or beliefs to satisfy the needs/wants of her guy.
As far as writing or reading the Boys out of character, I think I am still trying to figure how to write them, myself. I feel like I keep them in character most of the time, but I'm still working on that. I've said before that I tend to lean towards female characters because I think I can do a better job of characterizing a fictional female than I can characterizing one of the guys. That being said, I can only think of one time that a reader commented on a particular scene and insinuated that I was writing my Backstreet Boy out of character. That was Mare during the reading challenge, and she said something like "I have a hard time believing that he is more worried about X than he is about Y (the more pressing issue at the time)." I was actually really taken aback by it at the time, because that wasn't my intent at all in the particular scene she was reading. Though, looking back and re-reading, I could definitely see how she interpreted it that way.
Which brings me to another question: Have you ever been surprised by a reader's interpretation of something in your story? Maybe they read into something way more than you intended, or they just got a different vibe from the story than you were intending to give off? Did you modify your story after that feedback (if you were still in the process of writing) to better explain said situation, or try to explain in your response to the review, or neither and just let them interpret it as they interpreted it? I think one cool thing about writing /reading in general is that there can be so many different viewpoints on a single piece.